Figure 4.

Spatial memory learning of APP23 mice treated with TO901317. A, Time needed to reach the hidden platform (latency in seconds) and distance traveled (in centimeters) in the Morris maze by vehicle or TO901317 (TO)-treated APP23 (n = 16) and wild-type (WT) mice (n = 16). B, C, Integrated distance traveled (area under the curve) (B) and time (C) were determined for the whole observation period or divided in an acquisition (day 1–4) and a consolidation (day 5–8) phase. Asterisks indicate significant differences (Student's t test, *p < 0.05). D, TO901317 treatment does not reinstate place preference in the Morris water maze in APP23 mice. P, AL, O, and AR represent platform quadrant, and quadrant to the left, the right, and opposite of P, respectively. Data represent means ± SEM. Groups consisted of 16 animals. For detailed description of the statistics, see Results.