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. 2019 Aug 16;30(8):957–966. doi: 10.1089/hum.2019.012

Figure 3.

Figure 3.

Long-term expression of hIDUA in neurons. Immunostaining of hIDUA 3 years and 8 months post AAV9.hIDUA i.t. injection. Representative stains from the frontal cortex (A and B), cerebellum (C and D), and cervical spinal cord (E and F) are shown. Scale bars: (A, B, E, and F) 100 μm; (C and D) 200 μm. (G) Quantification of hIDUA-positive neurons (% of total two neurons) in deep layers of the frontal cortex, hippocampus layers CA2-CA3, Purkinje cell layer in the cerebellum, cervical, thoracic, lumbar spinal cord anterior horns, cervical, thoracic, and lumbar DRG. Negative control = untreated rhesus monkey tissues stained with the same hIDUA antibody.