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. 2019 Aug 16;30(8):957–966. doi: 10.1089/hum.2019.012

Figure 4.

Figure 4.

Representative histology of DRG, spinal cord axons, and peripheral nerves. Microscopic images of central and peripheral nervous system tissues of rhesus monkeys administered AAV9 vector expressing human IDUA via intrathecal cervical injection at 4 weeks of age. There were no test article-related microscopic findings in either the tolerized or non-tolerized cohort. The images are representative of the central and peripheral nervous system tissues from each cohort. The cervical DRG (A and D), thoracic spinal cord (B and E), and sciatic nerve (C and F) were microscopically normal in all animals. Hematoxylin and eosin staining. Scale bars: (A, C, D, and F) 100 μm; (B and E) 200 μm.