Figure 4.

GQ-11 improves wound closure in db/db mice. (A) Representative lesions at scapula of nondiabetic mice (postsurgery and after 7 days), decrease of wound area along 7 days postsurgery and total wound closure. (B) Representative lesions at scapula of diabetic db/db mice (postsurgery and after 10 days), decrease of wound area along 10 days postsurgery and total wound closure. Mice were submitted to surgical procedure to induce scapula lesions and were treated at the 3rd day postsurgery with vehicle (CTRL—Pluronic Gel^®), pioglitazone (PIO—2 mM), or GQ-11 (2 mM) for 4 days (nondiabetic mice) and 7 days (db/db mice). Positive controls [CTRL (+)] are represented by wounds of nondiabetic mice at the 3rd day postsurgery without treatment. Data are expressed as the mean ± SD of six mice per group. Statistical analyses were performed using ANOVA/Tukey's multiple comparison tests. *p < 0.05.