Figure 6.

GQ-11 decreases macrophage infiltration in wounds of db/db mice. (A) Representative sections of Mac-3 staining in wounds of nondiabetic mice. (B) Representative sections of Mac-3 staining in wounds of db/db mice. Mice were submitted to surgical procedure to induce scapula lesion and were treated at the 3rd day postsurgery with vehicle (CTRL—Pluronic Gel), pioglitazone (PIO—2 mM), or GQ-11 (2 mM) for 4 days (nondiabetic mice) or 7 days (db/db mice). Positive controls [CTRL (+)] are represented by wounds of db/+ mice at the 3rd day postsurgery without treatment. Histological sections were collected with frozen samples with cryostat and staining was performed by immunohistochemistry with specific antibodies against Mac-3 (1:50). Magnification 10 ×.