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. 2019 Aug 13;6(1):e000270. doi: 10.1136/lupus-2018-000270

Figure 3.

Figure 3

Schematic picture of the type I interferon production and different nucleic acid sensors. cGAMP, cyclic GMP-AMP; cGAS, cyclic GMP-AMP synthase; DAI, DNA-dependent activator of IFN-regulatory factors; DDX41, DEAD-box helicase 41; DNA-PKcs, DNA-dependent protein kinase; ER, endoplasmatic reticulum; FCGRIIA, Fc-gamma receptor II A; IC, immune complex; IFI16, gamma-interferon-inducible protein 16; IRAK, interleukin-1 receptor–associated kinase; IRF, interferon regulatory factor; MAVS, mitochondrial antiviral-signalling protein; MDA5, melanoma differentiation–associated protein 5; MyD88, myeloid differentiation primary response 88; NET, neutrophil extracellular traps; RIG-I, retinoic acid–inducible gene I; STING, stimulator of interferon genes; TLR, Toll-like receptor; TRAF6, TNF receptor–associated factors; TREX1, three prime repair exonuclease 1.