Skip to main content
. 2011 Oct 12;31(41):14775–14782. doi: 10.1523/JNEUROSCI.2923-11.2011

Figure 1.

Figure 1.

Chemical structure of substances activating hTAS2R46 (A) and substances not activating hTAS2R46 (B). The nomenclature of the carbon atoms is indicated. C, Activation of hTAS2R-expressing cells during bath application of 3HDC (100 μm). D, Activation of hTAS2R-expressing cells during bath application of 3HP (100 μm). HEK293T cells were transfected with cDNA for the indicated hTAS2Rs or empty vector (mock). Calcium signals elicited by the stimuli were recorded in the FLIPR. Arrows point to positive responses that were verified by replicates (n = 3). Apparent activation of hTAS2R38 by 3HDC is attributable to DMSO content of the test substance solution (Meyerhof et al., 2010). Scale: y, 15,000 counts; x, 8 min.