#	Searches	Results
1	Drug Costs/	11364
2	Economics, Pharmaceutical/	2379
3	Fees, Pharmaceutical/	1105
4	Prescription Fee/	939
5	exp Pharmaceutical Preparations/ec [Economics]	4131
6	Drug Prescriptions/ec [Economics]	2562
7	Drug Substitution/ec [Economics]	36
8	or/1‐7	18829
9	exp Pharmaceutical Preparations/	587714
10	Drug Prescriptions/	20886
11	Drug Substitution/	487
12	or/9‐11	606182
13	Economics/	26629
14	Health Expenditures/	12736
15	"Costs and Cost Analysis"/	40253
16	Health Care Costs/	24066
17	Cost Control/	19418
18	Cost Savings/	7866
19	Commerce/	16300
20	"Rate Setting and Review"/	2438
21	or/13‐20	138351
22	Policy/	457
23	Health Policy/	47001
24	Health Care Reform/	26362
25	National Health Programs/	23941
26	Policy Making/	11218
27	Government Regulation/	16371
28	Legislation, Drug/	8329
29	Politics/	38756
30	(policy or policies or politics or plan or plans or planning or program* or regulat* or legislat*).ti,ab.	1890437
31	or/22‐30	1987077
32	((reference or index or volume based or reimburs* or best available) adj3 (price or prices or pricing) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	141
33	((max* or minim* or reimburs* or ceiling or fixed) adj3 (price or prices or pricing or cost or costs) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	219
34	((price or prices) adj3 (control or controls or caps or negotiat* or compar* or cut or cuts or freez*) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	156
35	((price volume or cost plus) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	5
36	(profit adj3 (regulat* or limit*) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	1
37	((procure* or purchas* or rebate or acquisition or econom* or financ* or sale?) adj3 (policy or policies or intervention?) adj3 (drug or drugs or pharmaceutic* or medicines or medicat*)).ti,ab.	57
38	or/32‐37	493
39	((drug or drugs or pharmaceutic* or medicines or medicat*) adj6 (cost or costs or fee or fees or expenditure? or expense? or price or prices or pricing or spending? or purchas* or procure* or acquisition or sale?) adj6 (policy or policies or intervention? or politics or plan or plans or planning or program* or regulat* or legislat*)).ti,ab.	1491
40	8 and 31	5191
41	12 and 21 and 31	1508
42	38 or 39 or 40 or 41	6931
43	randomized controlled trial.pt.	340079
44	controlled clinical trial.pt.	85448
45	multicenter study.pt.	151515
46	(randomis* or randomiz* or randomly).ti,ab.	487333
47	groups.ab.	1210865
48	(trial or multicenter or multi center or multicentre or multi centre).ti.	128649
49	(intervention* or controlled or control group or compare or compared or (before adj5 after) or (pre adj5 post) or pretest or pre test or posttest or post test or quasiexperiment* or quasi experiment* or evaluat* or effect? or impact? or time series or time point? or repeated measur*).ti,ab.	6850206
50	or/43‐49	7373617
51	exp Animals/	16427399
52	Humans/	12629645
53	51 not (51 and 52)	3797754
54	comment.pt.	521909
55	editorial.pt.	319891
56	cochrane database of systematic reviews.jn.	9224
57	comment on.cm.	521908
58	review.pt.	1748075
59	review.ti.	227088
60	or/53‐59	6198639
61	50 not 60	5001053
62	42 and 61	2934
63	201012*.ed. or 2011*.ed,yr. or 2012*.ed,yr.	2315721
64	62 and 63	481