TABLE 1.
RNA-seq quantification of genes associated with early and late keratinocyte differentiation
| Differentiation stage |
Gene name | Mean expression level (in TPM)a
: |
|||
|---|---|---|---|---|---|
| NOKs |
NOKs-Akata |
||||
| Undiff. | +MC | Undiff. | +MC | ||
| Late | Loricrin | 0.0 | 0.1 | 0.0 | 0.1 |
| Filaggrin | 0.2 | 0.5 | 0.3 | 1.2 | |
| Early | Involucrin | 0 | 99 | 0 | 12 |
| Cornifin 1A | 1 | 1,824 | 0 | 836 | |
| Cornifin 1B | 18 | 5,587 | 3 | 3,421 | |
| Cornifin 2A | 2 | 341 | 0 | 148 | |
| Cornifin 2B | 3 | 206 | 1 | 157 | |
| Cornifin 3 | 0 | 2,040 | 0 | 280 | |
| Transglutaminase 1 | 1 | 715 | 1 | 408 | |
| Transglutaminase 3 | 0 | 41 | 0 | 8 | |
| Transglutaminase 5 | 0 | 40 | 0 | 10 | |
a
TPM, number of transcripts per million. Values are means for undifferentiated (undiff.) or MC-differentiated (+MC) NOKs or NOKs-Akata for each gene, grouped according to association with early or late keratinocyte differentiation.