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. 2012 Apr 18;32(16):5631–5637. doi: 10.1523/JNEUROSCI.6428-11.2012

Figure 3.

Figure 3.

Stimulation induced a task-specific reduction in striatal activity during stimulus switching. A, The statistical parametric maps were masked by the main effect of stimulus switching (thresholded at p < 0.001 uncorrected). The 3-way interaction of TMS Site (M1 vs medial parietal cortex) × TMS Time (pre-TMS vs post-TMS) × Task revealed a significant effect in the putamen. TMS had a different effect on BOLD signal in the putamen during stimulus switching depending on whether stimulation was applied to M1 or medial parietal cortex. B, This interaction was driven by a significant effect of M1 TMS, and no significant effect of TMS over the medial parietal cortex (not displayed). Bar indicates t values and figures are thresholded for a t value of 3.25 corresponding to a p value of 0.001 uncorrected for multiple comparisons. C, Bar graphs (representing parameter estimates extracted from the peak voxel of the 3-way interaction [MNI coordinates: (−18, 8, 2)] (cluster shown in A)) showing that TMS over M1, but not the medial parietal cortex, decreased BOLD signal in the anterior putamen during stimulus switching.