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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2018 Sep 26;61(19):8658–8669. doi: 10.1021/acs.jmedchem.8b00655

Figure 3.

Figure 3.

Expansion of Vγ9Vδ2 T cells from PBMCs by phosphonamidate prodrugs. A) Following 3 days of compound exposure and 11 days of proliferation, the number of Vγ9Vδ2 T cells was assessed. Data are representative of 3 independent experiments using a concentration of 100 nM of each positive control and each test compound. B) Compounds were assessed for activity in dose response experiments, in comparison to non-stimulated cells (NS) and the positive controls HMBPP (HM) and POM2-C-HMBP (POM2) at 100 nM. Data shown is from three independent experiments each using a minimum of two different human donors.