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Stability of compounds in 50% pooled human plasma in PBS.
| Compound | 2 hour fraction remaining (SD) | 24 hour fraction remaining (SD) | t1/2 |
|---|---|---|---|
| POM2-C-HMBP (2) | 0.048 (0.034) | N.D. | 0.14 h |
| 9a | 0.97 (0.055) | 0.90 (0.11) | >24 h |
| 9b | 1.0 (0.042) | 0.96 (0.12) | >24 h |
| 9c | 0.99 (0.029) | 0.92 (0.050) | >24 h |
| 9d | 0.97 (0.035) | 0.76 (0.029) | >24 h |
| 9e | 1.0 (0.0071) | 0.89 (0.014) | >24 h |
| 9f | 1.0 (0.0071) | 0.95 (0.0071) | >24 h |
| 9g | 1.0 (0.0071) | 0.82 (0.0071) | >24 h |
| 9h | 1.0 (0.021) | 0.92 (0.035) | >24 h |
| 9i | 1.0 (0.085) | 0.95 (0.12) | >24 h |
