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. Author manuscript; available in PMC: 2019 Oct 11.
Published in final edited form as: J Med Chem. 2018 Sep 26;61(19):8658–8669. doi: 10.1021/acs.jmedchem.8b00655

Table 4.

Interferon γ production by Vγ9Vδ2 T cells in response to K562 cells loaded for 4 hours with test compounds.

Compound EC50 [µM] (95% CI)
9a 0.46 (0.29 to 0.71)
9b 0.17 (0.070 to 0.42)
9c 0.74 (0.42 to 1.3)
9d 0.13(0.11 to 0.15)
9e 0.062(0.037 to 0.11)
9f 0.29 (0.14 to 0.59)
9g 0.12 (0.056 to 0.26)
9h 0.093 (0.069 to 0.13)
9i 0.21 (0.15 to 0.30)
Mean
Ar = phenyl		 0.46
Mean
Ar = 1-naphthyl		 0.16
Mean
Ar = 2-naphthyl		 0.14
Mean
R = methyl		 0.24
Mean
R = ethyl		 0.11
Mean
R = isopropyl		 0.41