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Model representing the mechanism of signaling via secreted Wg that can act up to a distance of at least 11 cells. Cells beyond the range of secreted Wg can maintain Dll expression by upregulating positive regulators, e.g. the Fz2 receptor. Persistence of membrane-tethered NRT-Wg mediates signaling up to a few cell distances, beyond which cells depend on higher levels of Fz2 to maintain target gene expression.
