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. 2019 Aug 2;146(15):dev170241. doi: 10.1242/dev.170241

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© 2019. Published by The Company of Biologists Ltd

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Fig. 10. — Notch signaling is required for normal development of the tendon-bone attachment unit. (A,B) μCT analyses at P21 show that Wnt1-Cre; Notch2^flx/flx mandibles have smaller and morphologically irregular condyle and angular process compared with controls. (C,D) Wnt1-Cre; Jagged1^flx/flx mandibles at P17 also have a smaller condyle and angular process (arrowhead). (E-H) Whole-mount skeletal preparations from control and Wnt1-Cre; Notch2^flx/flx at P21 and Wnt1-Cre; Jagged1^flx/flx at P17 reveal that the ridge for the masseter tendon on the angular process is missing (asterisks). (G,H) In the Wnt1-Cre; Jagged1^flx/flx mandible, the articular surface of the condyle is missing (arrowhead). (I-J) Morphometric analyses show that the relative condyle length in Wnt1-Cre; Notch2^flx/flx (I) and Wnt1-Cre; Jagged1^flx/flx (J) mandibles are truncated (n=4 same-sex littermate pairs). *P<0.05, ***P<0.001 (two-tailed t-test). Error bars represent s.e.m. Scale bars: 1 mm.