Figure 2.

Functional recordings in monkey DRGs confirm the absence of P2X2/3 channels. A, Representative rat and monkey DRG neurons (arrow) in culture. B, C, Recordings from rat and monkey DRG neurons showing action potentials evoked upon depolarization (B) and P2X3 currents evoked by αβmeATP (10 μm, bar) (C). D, E, Currents generated by multiple applications of αβmeATP in cells with transient (D) or sustained (E) current profiles. Contrary to rat DRGs, none of the 256 monkey DRG neurons recorded displayed P2X2/3-like currents.