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. 2012 Sep 12;32(37):12673–12683. doi: 10.1523/JNEUROSCI.0016-12.2012

Figure 3.

Figure 3.

MEC-17 deficiency affects the morphology of cortical projection neurons in the IZ region but does not affect radial glia organization, survival, or cell division. A–C, Coronal sections of rat cortex at E18.5, which were electroporated at E16.5 with control shRNA or MEC-17 shRNA-a along with a GFP-expressing plasmid, were immunostained for the indicated markers (red) including the radial glia organization marker nestin (A), the cell apoptosis marker cleaved Caspase-3 (B), and the cell division marker Ki-67 (C). D, Coronal sections of rat cortex in the IZ region and histogram showing the distribution of neurons at the multipolar stage, unipolar/bipolar stage (unbranched), and unipolar/bipolar stage with highly branched leading processes (branched) at P0 after MEC-17 depletion. Scale bars: A, 200 μm; B–D, 50 μm. **p < 0.01, ***p < 0.001 versus control shRNA; #p < 0.05, ##p < 0.01, ###p < 0.001 versus MEC-17 shRNA-a. All data represent the means ± SEM.