Fig. 5. Manhattan plots of unadjusted −log₁₀ (P values) for phecodes observed before age 40.

Each point shows one phecode. All associations with P < 0.01 are annotated. For females, the conditions with P values between 0.05 and 0.01 include alteration of consciousness, abnormality of gait, convulsions, obstructive sleep apnea, abnormal movement, sleep apnea, chronic venous insufficiency, other diseases of the teeth and supporting structures, endometriosis, inflammatory diseases of the uterus (except cervix), noninflammatory disorders of the vulva and perineum, disorders of menstruation and other abnormal bleeding from the female genital tract, complications of labor and delivery, hyperhidrosis, acne, cellulitis and abscess of the leg (except the foot), diseases of the sebaceous glands, chronic ulcer of the skin, synovitis and tenosynovitis, intervertebral disc disorders, disorders of the coccyx, thoracic or lumbosacral neuritis or radiculitis, symptoms of the muscles, swelling of limbs, malaise and fatigue, and myalgia and myositis. For males, the conditions with P values between 0.05 and 0.01 include other symptoms of the respiratory system, other diseases of the respiratory system, personality disorders, depression, orchitis and epididymitis, gingival and periodontal diseases, disorders of carbohydrate transport and metabolism, intestinal disaccharidase deficiencies and disaccharide malabsorption, disorders of the function of the stomach, dyspepsia, and other specified disorders of the function of the stomach.