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. 2019 Aug 21;39(34):6696–6713. doi: 10.1523/JNEUROSCI.0827-19.2019

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Copyright © 2019 Dillingham et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — MTT lesions were associated with a decrease in both number (A) and clustering (B) of spines in the basal dendrites of Golgi-stained CA1 pyramidal neurons in Cohort 2a. Performance on a T-maze task was impaired in MTT lesion animals relative to controls in Cohort 2a and Cohort 2b (C). DCX is a marker of adult neurogenesis; in Cohort 2b, MTT lesions resulted in a decrease in the complexity of DCX⁺ neurons (D) as well as a decrease in the stereologically estimated overall number of DCX⁺ neurons in the dentate gyrus (DG; E). Cohort 2a (lesion, n = 9; controls, n = 12); Cohort 2b (lesion, n = 12; control, n = 8). Central schematic diagram represents the morphology and anatomical location of neurons that were sampled. *p < 0.05; ***p < 0.001.