Figure 13.

Tau inclusions with exogenous human tau lacking endogenous mouse tau in tau-Tg mice. A–D, Brain sections of 10-month-old PS19 mice were labeled for endogenous mouse tau (anti-rodent tauN; green; A), exogenous human tau (RTM49; blue; B), and AT8 (red; C). The hippocampal CA1 is shown. A merged view is shown in D. AT8-positive tau inclusions were colabeled with the antibody for human tau (arrow) but not for endogenous mouse tau. The line was used for the analysis in E. Scale bar, 20 μm. E, Line scan analysis of mouse and human tau and AT8 immunoreactivity in D. The arrow indicates the position of cytoplasmic inclusions positive with AT8.