Figure 14.

Lack of tau pathology in aged P301L-KI mice. Homozygous P301L-KI mice were crossbred with APP-Tg mice (Tg-2576) and the amyloid and tau pathologies were examined by immunostaining with anti-amyloid β (A, B) and AT8 (C, D) antibodies at 18 months of age. Sections from AD brains were used for positive controls (B, D). The abundant senile plaques were detected in both aged crossbred mice and AD brains (A, B). Tau-related pathologies, such as NFts (large arrows), neuropil threads (small arrows), and dystrophic neurites around senile plaque (arrowheads), were found in an adjacent section of the human brain (D), but none of them was detected in the mouse brain (C). Asterisks and hashmarks indicate the same blood vessels appeared on the adjacent brain sections. Scale bar, 100 μm.