Figure 2.

In vivo catabolism and RCT of plasma HDL CO. ³H-CO radiolabeled human HDL was injected intravenously in control (n=6) and HSKO (n=6) mice with ¹²⁵I-TC HDL (see Figure 1). Periodic blood samples were taken over 24 or 48 hours in two separate experiments to analyze plasma decay (A), plasma FCR (B), plasma HDL ³H-CO selective clearance, using data from Figure 1B for ¹²⁵I-TC FCR (C), liver ³H-radiolabel accumulation (D), and fecal ³H-radiolabel excretion (E). Data are mean ± SEM. Control turnover curves in panel A are nearly identical and SEM in nearly all points falls within the symbol. **p < 0.01; ***p < 0.001.