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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Jun 6;39(9):1747–1761. doi: 10.1161/ATVBAHA.119.312382

Figure 8.

Figure 8.

Macrophage reverse cholesterol transport. Control (n=6) and HSKO (n=6) mice were injected intraperitoneally with 3H-cholesterol-loaded J774 macrophages. Blood samples were taken over 96 hours to monitor plasma appearance of 3H-radiolabel (A). 48-hour plasma samples were fractionated by FPLC to determine 3H-radiolabeled lipoprotein distribution (B). At 96 hours, mice were sacrificed and liver 3H radiolabel uptake was measured (C). Feces were collected from 0-48 hours and 48-96h and 3H-radiolabeled cholesterol (Chol) and bile acid (BA) excretion were quantified (D). Total sterol 3H-radiolabel = Chol + BA radiolabel. Data are mean ± SEM.