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. Author manuscript; available in PMC: 2019 Aug 21.
Published in final edited form as: Annu Rev Nutr. 2019 Jun 10;39:291–315. doi: 10.1146/annurev-nutr-082018-124320

Figure 3.

Figure 3

Pervasive benefits of time-restricted feeding. Chronic circadian rhythm disruption is a risk factor for metabolic diseases. Studies in animal models (flies, mice, rats) and emerging studies in humans show that time-restricted feeding protects metabolic tissues from metabolic disturbances. Time-restricted feeding may also benefit brain health and could delay the development of neurodegenerative diseases. Abbreviations: ETC, electron transport chain; ROS, reactive oxygen species; UCP, uncoupling protein.