Transmission electron microscopy images of HA-based NPs that were derived from 10 kDa or 100 kDa HA, using either PBA or 5βCA as hydrophobic substituents to drive self-assembly (scale bars = 100 nm). The subscript “100” or “10” refers to 100 or 10 kDa HA, respectively. “H”, “L”, and “Ø” refer to high, low, or no hydrophobic ligand conjugation to HA. (adapted from Hill et al. [48] Copyright © Ivyspring International Publisher, 2016).