Skip to main content
. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Feb 21;151-152:245–261. doi: 10.1016/j.addr.2019.02.004

Figure 4:

Figure 4:

Time-dependent differences in adrenal suppression following methylprednisolone infusions. The time-concentration profiles of 17-OHCS, a metabolite of cortisol excreted in urine, are shown following 4-hour methylprednisolone infusions for the following time windows: 00:00 to 04:00, 04:00 to 08:00, 08:00 to 16:00, and 16:00 to 20:00. Solid circles represent the control (no drug infusion) and open squares represent the drug-modified cortisol rhythm. Figure drawn using data from Angeli A. Circadian ACTH-adrenal rhythm in man. Chronobiologia. 1974 Sep;1 Suppl 1:253–68. Reprinted from: Haus E, Sackett-Lundeen L, Smoilensky MH. Rheumatoid arthritis: circadian rhythms in disease activity, signs and symptoms, and rationale for chronotherapy with corticosteroids and other medications. Bull Hosp Jt Dis. 2012;70(Suppl 1):S3–10. With permission.