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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Feb 21;151-152:245–261. doi: 10.1016/j.addr.2019.02.004

Figure 7:

Figure 7:

Modeling chronopharmacological dosing of synthetic glucocorticoids using a physiologically-based HPA axis model. The concentration-time profiles for a bolus injection, fast-releasing oral dose, and a slow-releasing oral dose are given in Panel A. The nominal cortisol profile predicted by the model is given in Panel B. The relative amplitude change (%difference in amplitude before and after once-daily dosing of synthetic glucocorticoids) are given for several dosing times in Panel C, where a positive value indicates induction of the cortisol rhythm and a negative value indicates suppression of the cortisol rhythm. The difference in phase of the cortisol rhythm before and after treatment with synthetic glucocorticoids for several dosing times are given in Panel D, where a positive value indicates delayed timing of the cortisol peak and a negative value indicates an advance in the timing of the cortisol peak. Figure drawn using data from R.T. Rao, M.L. Scherholz, I.P. Androulakis, Modeling the influence of chronopharmacological administration of synthetic glucocorticoids on the hypothalamic-pituitary-adrenal axis, Chronobiol Int, (2018) 1–18.