Table 3. Baseline characteristics of ACPA-positive/Rheumatoid Factor-positive patients that progressed to RA and did not progress to RA during 2 year follow-up.
| Patient characteristic | Convertors (N=12) |
Non-convertors (N=6) |
p-value | ||
|---|---|---|---|---|---|
| Age in years, mean (SD) | 45 | (15) | 49.8 | (11) | 0.50 |
| Female sex, n (%) | 9 / 12 | (75) | 5 / 6 | (83) | 0.69 |
| Family history of RA, n (%) | 4 / 12 | (33) | 0 / 6 | (0) | 0.11 |
| 68-TJC, median (IQR) | 5.0 | (3–8) | 5.5 | (2–9) | 0.87 |
| CRP | |||||
| Elevated CRP (>10 mg/L), n (%) | 5 / 12 | (42) | 2 / 6 | (33) | 0.73 |
| CRP-level, median (IQR) | 4.7 | (3–12) | 4.2 | (3–6) | 0.32 |
| IgM-RF level (IU/mL), mean (SD) | 76.6 | (77) | 79.2 | (64) | 0.93 |
| ACPA-level (U/mL), mean (SD) | 222.8 | (125) | 211.0 | (141) | 0.87 |
| MRI positive for inflammation | |||||
| Any inflammation present, n (%) | 9 / 10 | (90) | 5 / 6 | (83) | 0.70 |
| Total RAMRIS score, median (IQR) | 5.8 | (3–19) | 5.8 | (4–11) | 0.36 |
Symptoms were noted by rheumatologists as reported by the patients.
Glossary: ACPA = anti-citrullinated peptide antibody; CRP = c-reactive protein; IgM-RF = immunoglobulin M rheumatoid factor; IQR = interquartile range; MRI = magnetic resonance imaging; RA = rheumatoid arthritis; RAMRIS = Rheumatoid Arthritis MRI scoring system; SD = standard deviation; TJC = tender joint count.