Table 2. Interaction of hyperbaric pressure and the use of pharmacologic agents in human studies; ATA − atmospheres absolute pressure; DCT − decompression time; LoE − level of evidence; MTC − mega thrombocyte; n − number; OW(HL) − open water (Hydrolab); PC − pressure chamber; RBC − red blood cell count; resp − respiratory; VK744 − analogue of dipyridamole .

Reference	n	Drug	Control	Pressure (ATA)	Bottom time	Location	Blinded	Outcome	Results	LoE
12	20	Aspirin	Placebo	2.4	60 h	OW(HL)	Yes	Platelet count	Reduced platelets in control group	Ib
12	12	VK744 (dipyridamole)	Placebo	2.4	5 days (incl. DCT)	OW(HL)	Yes	Platelet count	Greater elevation of MTC in VK744; reduced platelets in control group	Ib
11	24	Aspirin; Dipyridamole	Placebo	2.8	48 h	PC	Yes	Platelet count and function	Reduced platelets in dipyridamole and control groups	Ib
13	10	Scopolamine	Placebo	2.8	5.5 days	PC	Yes	Cognitive	No significant effects	Ib
14	24	Scopolamine	Placebo	4.8	11 min	PC	Yes	Cognitive	No significant effects	Ib
21	102	Clemastine fumarate	Placebo	6.1	20 min	PC	Yes	Cognitive	No significant effects	Ib
15	30	Pseudoephedrine; Dimenhydrinate	Placebo	3.0	30 min	PC	Yes	Cognitive	Pseudoephedrine nil effects; dimenhydrinate reduced performance	Ib
17	24	Pseudoephedrine; Cyclizine	Placebo	4.0	5 min	PC	Yes	Cognitive	Pseudoephedrine nil effects; cyclizine reduced performance	Ib
18	30	Oral contraceptives	None	3.5	25 min	OW	No	Bubble production	No differences	IV
19	1	Bleomycin	None	Multiple	Multiple	OW	No	Resp. distress or fatigue	No complications	V
20	1,608	Psychotropic drugs	None (survey)	Multiple	Unknown	OW	No	Narcosis (severe)	No significant effects	IIb