Interleaved low-high floating bar plot (line at mean) showing MUCCA (mm2) in subjects with with lesions (clear) and without lesions (striped) per segmentation method (SCT-PropSeg [red], SCT-DeepSeg [yellow], NeuroQLab [blue], Xinapse JIM [pink], ITK-SNAP [green] and Manual [orange]). Differences can be seen between segmentation methods. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)