Table 4.
Unadjusted and adjusted effects of various blood and tissue eosinophil cutpoints on disease control.
| Eosinophil cutpoints n = 183 (% of patients) |
Unadjusted odds ratio (95% CI) |
Adjusteda odds ratio (95% CI) |
||
|---|---|---|---|---|
| Blood (×109/L) | Uncontrolled | Partly controlled | Uncontrolled | Partly controlled |
| ≥0.1 (79.8%) VS. < 0.1 (20.2%) | 1.14 (0.48–2.68) | 1.56 (0.64–3.82) | 1.08 (0.44–2.66) | 1.78 (0.69–4.58) |
| ≥0.2 (55.2%) VS. < 0.2 (44.8%) | 3.48(1.65–7.32)€ | 3.20(1.55–6.61)* | 3.22(1.46–7.12)* | 3.60(1.67–7.75)€ |
| ≥0.3 (42.6%) VS. < 0.3 (57.4%) | 3.56(1.69–7.49)€ | 2.19(1.06–4.55)$ | 3.30(1.45–7.49)* | 2.64(1.20–5.84)$ |
| ≥0.4 (27.3%) VS. < 0.4 (72.7%) | 3.39(1.48–7.76)* | 2.25 (0.97–5.23) | 3.09(1.30–7.34)$ | 2.55(1.06–6.12)$ |
| ≥0.5 (18.6%) VS. < 0.5 (81.4%) | 2.96(1.14–7.69)$ | 2.25 (0.85–5.95) | 2.65 (0.97–7.26) | 2.69 (0.97–7.42) |
| Tissue (%) | ||||
| ≥5 (59.0%) VS. <5 (41.0%) | 2.12(1.02–4.41)$ | 1.67 (0.82–3.38) | 1.81 (0.83–3.92) | 1.79 (0.85–3.78) |
| ≥10 (46.4%) VS. < 10 (53.6%) | 3.51(1.67–7.35)€ | 1.70 (0.83–3.46) | 3.08(1.39–6.82)* | 1.93 (0.90–4.16) |
| ≥15 (41.0%) VS. < 15 (59.0%) | 3.33(1.59–6.98)€ | 1.53 (0.74–3.18) | 2.94(1.36–6.38)* | 1.65 (0.77–3.56) |
| ≥20 (35.5%) VS. < 20 (64.5%) | 2.79(1.32–5.90)* | 1.61 (0.84–3.42) | 2.43(1.11–5.30)$ | 1.62 (0.74–3.55) |
Results in boldface indicate a P value of less than 0.05. $P < 0.05; *P < 0.01; €P < 0.001.
CI, confidence interval; VS, versus.
a
Results were adjusted for age, gender, smoking, prior sinus surgery, allergic rhinitis and asthma.