Fig. 6.

The grooves and the space in the lamin A11 tetramer. a The lamin tetramer is shown in the surface representation (grey), and the anti-parallel contact region is marked. Two ~4-nm-long grooves are in brown and enlarged in the top panel. The cross-sections, marked with a–g, are shown in the bottom panel. b The bent model of the full-length rod domain reflecting the crystal structure of the lamin A11 tetramer is shown in the left panel and the straightened model is shown in the right panel. The sub-domains are coloured differently as shown in Fig. 1a. The ~4 nm grooves and ~6-nm-long spaces are in brown and light grey, respectively. Detailed information for the model construction is depicted in Supplementary Fig. 5