Table 1.
Descriptive and statistical data of 74 study arms.
| rTMS Parameter | Significant Study Arms | Not significant Study Arms | p |
|---|---|---|---|
| n = 56 (75.68%) | n = 18 (24.32%) | ||
| N (%) | N (%) | ||
| Manufacturer TMS device | |||
| Magstim | 14 (77.78) | 4 (22.22) | |
| MagVenture/Medtronic | 34 (72.37) | 13 (27.66) | 0.76 |
| Default waveform | |||
| Biphasic cosine | 16 (80.00) | 4 (20.00) | |
| Biphasic sine | 36 (72.00) | 14 (28.00) | 0.56 |
| Stimulation position | |||
| Temporal cortex | 32 (78.05) | 9 (21.95) | |
| Temporo-parietal cortex | 23 (71.88) | 9 (28.12) | 0.54 |
| Auditory cortex stimulation laterality | |||
| Bilateral | 5 (66.67) | 1 (16.67) | |
| Unilateral | 50 (74.73) | 17 (25.37) | >0.99 |
| Auditory cortex stimulation hemisphere | |||
| Left | 36 (70.59) | 15 (29.41) | |
| Other (contralateral, ipsilateral, bilateral, left or right) | 19 (86.36) | 3 (13.64) | 0.24 |
| Stimulation frequency | |||
| Inhibitory (1 Hz, cTBS) | 49 (73.13) | 18 (26.87) | |
| Excitatory (10 Hz, 25 Hz) | 6 (100.00) | 0 (0.00) | 0.33 |
| Stimulation type | |||
| cTBS | 4 (80.00) | 1 (20.00) | |
| rTMS (1 Hz, 10 Hz, 25 Hz) | 50 (73.53) | 18 (26.47) | 0.33 |
| Motor threshold determination method | |||
| EMG | 36 (75.00) | 12 (25.00) | |
| Visual | 10 (76.92) | 3 (23.08) | >0.99 |
| Neuronavigation | |||
| Yes | 17 (73.91) | 6 (26.09) | |
| No | 38 (76.00) | 12 (24.00) | 0.85 |
| Prefrontal stimulation in addition to auditory cortex stimulation | |||
| Additional prefrontal stimulation | 9 (56.25) | 7 (43.75) | |
| No additional prefrontal stimulation | 46 (80.70) | 11 (19.30) | 0.04* |
| M ± SD | M ± SD | p | |
| Stimulation hemisphere - auditory cortical areas (left = 0; right = 1) |
0.12 ± 0.22 (n = 49) |
0.07 ± 0.21 (n = 17) |
0.66 |
| Stimulation intensity (%) |
103.53 ± 10.7 (n = 51) |
110.00 ± 3.54 (n = 17) |
0.02* |
| Number of sessions |
8.47 ± 3.38 (n = 55) |
9.22 ± 4.76 (n = 18) |
0.80 |
| Overall pulses per session − auditory and prefrontal cortical areas |
1807.64 ± 838.04 (n = 55) |
2488.89 ± 1095.92 (n = 18) |
0.03* |
| Pulses per session − auditory cortical areas |
1624.00 ± 671.85 (n = 55) |
1877.78 ± 662.04 (n = 18) |
0.21 |
| Overall total pulses − auditory and prefrontal cortical areas (pulses per session × number of sessions) |
16003.64 ± 11016.50 (n = 55) |
22333.33 ± 13266.50 (n = 18) |
0.07 |
| Total pulses − auditory cortical areas (pulses per session × number of sessions) |
14485.45 ± 9962.53 (n = 55) |
17277.78 ± 9730.52 (n = 18) |
0.20 |
*p ≤ 0.05.