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. 2019 Aug 21;9:12213. doi: 10.1038/s41598-019-48515-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High throughput generation of solid polymer microparticles. (a) Optical micrograph of droplet generators producing emulsion templates, with a dispersed phase of 4 wt% PCL of polycaprolactone (PCL) in dichloromethane (DCM) and a continuous phase of 2 wt% of polyvinyl alcohol (PVA) in water. (b) 9.0 L of emulsion collected by running our chip for an hour swith ɸ_c = 7.7 L/hr and ɸ_d = 1.2 L/hr. Top view (c) and side view (d) of a solid PCL microparticle. For both images scale bar: 2.8 μm. (e–g) SEM micrographs of three different formulations of PCL microparticles with different diameters d_p. Scale bar: 10 μm. (h) Histograms of the particle diameters: d_p = 9.0 µm (CV = 4.0%) (green), d_p = 7.6 µm (CV = 4.3%) (orange), and d_p = 5.3 µm (CV = 4.6%) (pink) respectively.