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. 2019 Aug 21;2:317. doi: 10.1038/s42003-019-0563-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — NVs improve inflammatory and metabolic profile in obese mice. a Biochemical parameters were analyzed in blood samples of mice fed with high-fat diet (HFD) or HFD supplemented with NVs isolated from J. californica (HFD + NV). Reference values were reported as blue dashed lines. b Oral glucose tolerance test (OGTT) was performed in mice fed with HFD or HFD supplemented with NVs (HFD + NV). Blood samples were collected at several time points from glucose administration. Values of mice fed with normal diet (ND) were reported as blue dashed lines. c, d Total body (c) and fat mass (d) weights of mice fed with HFD or HFD + NV. ND: mice fed with normal diet. e TNF-α mRNA expression in vWAT and BAT of mice fed with HFD or HFD + NV. f, g Cytokines antibody array was performed in total pool homogenate of mouse vWAT (n = 6 mice each group) fed with HFD or HFD + NV. Profiling Proteins: spotted cytokine antibodies; Reference Spot: spotted loading control; Control (−): PBS. Mean pixel spot density of each cytokine detected through antibody array showed in g. Data are expressed as means ± SD (n = 6 mice each group)