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. 2019 Aug 21;10:3761. doi: 10.1038/s41467-019-11696-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — JDP2 confers resistance to genotoxic stress on cancer cells in vivo. a Representative images of tumor-bearing nude mice inoculated intraperitoneally with the indicated cells in response to Topotecan chemotherapy at the indicated times (left), and the relative change in the bioluminescence signal of intraperitoneal tumors in nude mice in response to Topotecan chemotherapy (right). n = 6 animals per group. b Kaplan–Meier survival of mice inoculated intraperitoneally with the indicated cells. n = 6 animals per group. c Relative levels of GSH (left) and ROS (right) in the indicated xenograft tumors. d IHC staining of JDP2 expression and TUNNEL analysis (left) and quantification (left) of the apoptotic index in the indicated xenograft tumors. Scale bar, 20 μm. Each error bar in panels c and d represents the mean ± SD of three independent experiments. *P < 0.05. Student’s two-tailed t test. Source data of Fig. 9a–d are provided as a Source Data file