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. 2019 Aug 21;9:12167. doi: 10.1038/s41598-019-48548-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal trajectory of selected examples of DMD serum protein biomarkers and their association with age. CK-M remained relatively stable over time in young GC-naïve DMD patients (p = 0.506) and in controls (p = 0.622) within the age range studied. Myosin-binding protein C declined over time in DMD (p = 0.0477) and remained unchanged over time in controls. Gelsolin neared significance in its association with age (p = 0.0598); it decreased over time in untreated DMD patients while slightly increasing with age in controls. Alanine aminotransferase-1 while elevated in DMD relative to control remained stable over time in both DMD (p = 0.607) and controls. Green lines are DMD patients (n = 12) and black lines are healthy controls (n = 5). The dashed line represent the regression line in each group. P values are adjusted for multiple testing.