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. 2019 Aug 21;9:12206. doi: 10.1038/s41598-019-48432-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NOTCH3 regulates PDE5 expression. Representative western blot showing decrease of PDE5 protein levels in human VSMCs transfected with NICD1 and increase of PDE5 expression upon NICD3 intracellular domain transfection in human VSMCs (A) and in U87MG cells (B). Bottom panel in (A) represents densitometric analysis on four independent experiments. Bars represent ±SD *p < 0.05. Representative semi-quantitative RT-PCR showing mRNA levels of total PDE5A, PDE5A1, A2 and A3 isoforms in NICD1 or NICD3 overexpressing human VSMCs (C). Three independent experiments were performed.