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. 2019 Aug 21;9:12191. doi: 10.1038/s41598-019-48400-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Arp2/3 complex activity is required for microridge formation and maintenance. Confocal microscopy analyses of phalloidin stained embryos and larvae (a–i) treated with 1% DMSO (a,d,g), 100 µM CK689 (inactive drug control; b,e,h) and 100 µM CK666 (Arp2/3 complex inhibitor; c,f,i) for 1 hour from 9–10 hpf (a–c), 18–19 hpf (d–f) and 47–48 hpf (g–i). In all cases, inhibition resulted in a breakdown of microridges or a decrease in phalloidin punctae relative to controls. Images from 19 and 48 hpf are acquired from the head epidermis. Scale bar are equivalent to 10 µm.