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. 2019 Aug 21;9:12221. doi: 10.1038/s41598-019-48759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of STV-Na on behavioral deficits and brain infarct volume in mice with MCAO/R injury. Multiple tests were performed in mice that underwent 1 h of ischemia followed by 1 d, 3 d, 7 d or 14 d of reperfusion. (A) Dose-dependent effects of STV-Na on infarct volumes evaluated by TTC at 24 h (n = 6 per group). (B) A sample of brain slices TTC staining at 24 h after MCAO/R. (C) MNSS was evaluated at 24 h (n = 6 per group). (D) Effects of STV-Na on infarct volumes at different time points (n = 6 per group). (E) MNSS was evaluated at different time points (n = 6 per group). Data are represented as mean ± SD, ^*P < 0.05, ^**P < 0.01.