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. 2019 Aug 21;9:12221. doi: 10.1038/s41598-019-48759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STV-Na inhibits M1 polarization and promotes M2 polarization in BV2 microglial cells after OGD/R. Representative double-immunofluorescence staining for CD16/32 or CD206 and Iba-1 markers in BV2 microglial cells obtained from STV-Na or vehicle treatment after OGD/R, or from Normal. Scale bar: 100 μm. (A) BV2 microglial cells co-stained for CD16/32 (M1 marker) (red) and Iba-1(green). (B) BV2 microglial cells co-stained for CD206 (M2 marker) (red) and Iba-1 (green). (C) Quantification of the percentage of CD16/32⁺/Iba-1⁺ cells among total Iba-1⁺ cells. (D) Quantification of the percentage of CD206⁺/Iba-1⁺ cell among total Iba-1⁺ cells. (E,F,G,H,I,J,K,L,M,N) RT-PCR analysis of M1 (MCP-1, iNOS, CD32, CD86, IFN-γ) and M2 (Ym1/2, Arg-1, CD206, BDNF, TGF-β) markers in BV2 microglial cells after OGD/R. Data are represented as mean ± SD, ^*P < 0.05, ^**P < 0.01, ^***P < 0.01, versus control; ^#P < 0.05, ^##P < 0.01, versus OGD/R group.