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. 2019 Aug 21;9:12221. doi: 10.1038/s41598-019-48759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GAS5 up-regulation is involved in miR-146a-5p down-regulation both in vivo and in vitro models of ischemic stroke. RT-PCR assay for the expression of GAS5 (A) and miR-146a-5p (B) at each time point in mice subjected to 1 h MCAO and at 0 h, 6 h, 12 h, 24 h, and 48 h of reperfusion (n = 3 per group). RT-PCR was used to detect the expression of GAS5 (D) and miR-146a-5p (E) in cultured BV2 microglia cells at each time point in BV2 microglial cells subjected to 4 h OGD and at 0 h, 6 h, 12 h, 24 h, and 48 h of reperfusion (n = 3 per group). (C) Pearson’s correlation analysis of the relationship between GAS5 and miR-146a-5p in the brain of mice subjected to MCAO/R surgery. (F) Pearson’s correlation analysis of the relationship between GAS5 and miR-146a-5p in BV2 microglial cells subjected to OGD/R treatment. Data are represented as mean ± SD, ^*P < 0.05.