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. 2019 Aug 21;9:12221. doi: 10.1038/s41598-019-48759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GAS5 is a target of miR-146a-5p and negatively regulates its expression. (A) The predicted position of miR-146a-5p binding site on the GAS5 transcript. (B) The wide type (GAS5-WT) and mutant GAS5 (GAS5-MUT) were co-transfected with miR-146a-5p mimic or control mimic (NC mimic) into BV2 microglia cells and luciferase activity was detected. (C) RT-PCR for the expression of miR-146a-5p in microglia after transfection with si-GAS5/siRNA-NC in the presence of OGD/R exposure. (D) RT-PCR for the expression of miR-146a-5p in BV2 microglia cells after transfection with pcDNA3.1-GAS5/pcDNA3.1-NC in the presence of OGD/R exposure. ^*P < 0.05, ^**P < 0.01 versus Control; ^#P < 0.05, ^##P < 0.01.