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. 2019 Aug 21;9:12221. doi: 10.1038/s41598-019-48759-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GAS5 affect OGD/R-induced macrophage polarization by miR-146a-5p in BV2 microglia cells. To investigate whether GAS5 could affect OGD/R-induced macrophage polarization by regulating miR-146a-5p. The BV2 microglia cells were transfected or co-transfected with pcDNA3.1-GAS5/pcDNA3.1-NC and miR-146a-5p mimic/NC mimic. (A,B) The concentrations of TNF-α and IL-10 measured by ELISA. (C–E) RT-PCR detected the MCP-1, iNOS and CD32 mRNA expression levels. (F–H) RT-PCR detected the Ym1/2, Arg-1 and CD206 mRNA expression levels. Data are represented as mean ± SD, ^*P < 0.05, ^**P < 0.01.