Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 21;9:12179. doi: 10.1038/s41598-019-48717-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The effects of uPAR in cetuximab-resistant cells in vivo. (A) The tumor volume was calculated twice weekly after the injection. when the volume of the transplantation tumor reached 100 mm³ (arrows), the mice were treated with different drugs as indicated below (n = 3 per group). Significant antitumor growth activity by uPAR knockdown (shuPAR) combined with cetuximab is evident in SAS-R and Sa3-R cell xenografts. *P < 0.05. (B) The tumoral tissues from the shMock + DMSO, shMock + cetuximab, shuPAR + DMSO, and shuPAR + cetuximab were fixed in 10% formalin, and paraffin sections were prepared for hematoxylin and eosin (H&E) staining and immunohistochemistry (uPAR, integrin β1, ERK1/2, and p-ERK1/2). The scale bar indicates 50 μm.