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. 2019 Aug 21;9:12179. doi: 10.1038/s41598-019-48717-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity Pathway Analysis (IPA) of the canonical pathways for the cetuximab-resistant cells based on (A) increased expression of uPAR and (B) the predicted signaling pathway for uPAR inhibition by resveratrol leading to suppression of cetuximab-resistance in cancer cells. The pathways analyses were generated through the use of IPA (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis).