Table 1.
Study populations by the covariates used in the models
| SPRINT population | CHS population | |
|---|---|---|
| Characteristicsa | N = 9360 | N = 88,374 |
| Age, years | ||
| Mean ± SD | 67.9 ± 9.4 | 71.7 ± 10.7 |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| Sex | ||
| Female, n (%) | 3,331 (35.6%) | 41,713 (47.2%) |
| Male, n (%) | 6,029 (64.4%) | 46,661 (52.8%) |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| Black race | ||
| No, n (%) | 6,414 (68.5%) | 87,456 (99.0%) |
| Yes, n (%) | 2,946 (31.5%) | 918 (1.0%) |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| BMIb, kg/m2 | ||
| Mean ± SD | 29.9 ± 5.8 | 28.4 ± 5.0 |
| Missing, n (%) | 77 (0.8%) | 260 (0.3%) |
| Smoking category | ||
| Never, n (%) | 4,122 (44.0%) | 56,790 (64.3%) |
| Former, n (%) | 3,973 (42.4%) | 17,472 (19.8%) |
| Current, n (%) | 1,239 (13.2%) | 13,166 (14.9%) |
| Missing, n (%) | 26 (0.3%) | 946 (1.1%) |
| Clinical/subclinical CVD | ||
| No, n (%) | 7,483 (79.9%) | 58,526 (66.2%) |
| Yes, n (%) | 1,877 (20.1%) | 29,848 (33.8%) |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| Systolic BP, mmHg | ||
| Mean ± SD | 139.7 ± 15.6 | 139.9 ± 10.0 |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| BP medication types | ||
| 0–1, n (%) | 3,635 (38.8%) | 42,576 (48.2%) |
| 2–3, n (%) | 5,211 (55.7%) | 41,842 (47.3%) |
| ≥4, n (%) | 514 (5.5%) | 3,956 (4.5%) |
| Missing, n (%) | 0 (0.0%) | 0 (0.0%) |
| eGFR, mL/min/1.73 m2 | ||
| Mean ± SD | 71.7 ± 20.6 | 78.2 ± 21.1 |
| Missing, n (%) | 37 (0.4%) | 127 (0.1%) |
| Total cholesterol, mg/dL | ||
| Mean ± SD | 190.1 ± 41.2 | 188.0 ± 38.3 |
| Missing, n (%) | 38 (0.4%) | 134 (0.2%) |
| HDL, mg/dL | ||
| Mean ± SD | 52.9 ± 14.5 | 50.4 ± 13.4 |
| Missing, n (%) | 38 (0.4%) | 146 (0.2%) |
SPRINT systolic blood pressure intervention trial, CHS Clalit Health Services, SD standard deviation, BMI body mass index, kg/m2, CVD cardiovascular disease, BP blood pressure, eGFR estimated glomerular filtration rate, mL/min/1.73 m2, HDL high-density lipoprotein
aVariables were taken from the baseline characteristics of the SPRINT population and from the available EHR information prior to January 1st, 2013 for the CHS population
bBody mass index was measured as the weight in kilograms divided by the square of the height in meters