Table 2.

Gene signatures used for classification.

Signature	Reference	Type	Developed for
1. PAM50 – AIMS	23	GEP	All breast cancer
2. PAM50*	38	GEP	All breast cancer
3. IC10	11, 12	GEP	All breast cancer
4. CIT	27	GEP	All breast cancer
5. TNBCtype	28, 46	GEP	TNBC
6. HDPP	43	GEP	HER2+ breast cancer
7. SDPP	42	GEP	All breast cancer
8. SCMOD2	34	GEP	All breast cancer
9. GGI	39	RP	All breast cancer
10. Gene70	47	RP	All breast cancer
11. Oncotype DX	7	RP	ER+ breast cancer
12. Gene76	48	RP	LN-negative breast cancer
13. Endopredict	49	RP	ER+/HER2− breast cancer
14. Genius	37	RP	All breast cancer
15. ROR-S*	38	RP	All breast cancer
16. ROR-P*	38	RP	All breast cancer
17. ROR-T*	38	RP	All breast cancer
18. ROR-PT*	38	RP	All breast cancer
19. ROR-Tot*	8	RP	All breast cancer

*Implementation was performed by using a reference set similar in composition to Parker et al.³⁸ for gene centering.

GEP: Gene expression phenotype signature.

RP: Risk prediction signature.