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. 2019 Aug 21;8(9):46. doi: 10.1038/s41389-019-0154-y

Fig. 8. Model of FAC-induced pathogenesis of FTSECs compared with oncogenically transformed FTSECs.

Fig. 8

FAC-exposed FTSECs (for >2 months) demonstrated increased migration in addition to increased DNA damage/repair marker expression such as FANCD2. Furthermore, these cells had elevated hTERT mRNA. Transformed cells (as well as the iron-exposed cells) elicited increased cell numbers and expression of EVI1 variants, Myc, BMI1, and Cyclin D1. EVI1 knockdown markedly reduced hTERT transcript levels. β-catenin and BMI1 knockdown diminished c-Myc and Cyclin D1 proteins