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. 2019 Jun 25;161(9):1955–1964. doi: 10.1007/s00701-019-03980-8

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Boxplots of mean daily ICP and mean daily % time with PRx > 0 versus daily total TIL. ICP, intra-cranial pressure; MAP, mean arterial pressure; mmHg, millimeter of mercury; NS, non-significant; TIL, therapeutic intensity level; TTIL, total daily TIL. *p values reported are for the Jonckheere-Terpstra test for increasing mean values. Relationship between % time and PRx > 0 was non-significant for both increasing and decreasing mean values. Plot of mean daily % time with PRx above 0 versus daily TTIL a; Plot of mean daily ICP versus daily TTIL b; Plot of mean daily % time with PRx above 0 versus daily TTIL for time-shifted data c; Plot of mean daily ICP versus daily TTIL for time-shifted data d